Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.6
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
100 mg
†
Black Pepper Ext. (Piper nigrum) (fruit) (standardized to contain 95% Piperine) (BioPerine®)
5 mg
†
Top Medical Research Studies
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Read More
9
We explored the detrimental effects of chronic alcohol consumption on liver health, particularly focusing on how coenzyme Q10 (CoQ10) might help mitigate this damage. By conducting a study with rats, we investigated the relationship between ethanol-induced hepatotoxicity and the activation of specific inflammatory pathways.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
Read More
4
We aimed to understand how coenzyme Q10, an antioxidant, might influence patients suffering from non-alcoholic fatty liver disease (NAFLD). In our systematic review and meta-analysis, we examined various randomized controlled trials that utilized CoQ10 as part of the treatment regimen for NAFLD.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
Read More
Most Useful Reviews
9
Improved liver health
3049 people found this helpful
I want to share my experience with coenzyme Q10. I noticed numbness in my legs while sitting for long hours. After taking coenzyme Q10 daily for over two years, along with fish oil, my liver responded well, and the nocturnal pain diminished. I recently made a long car trip without leg issues, and I no longer feel cold in winter. Coenzyme Q10 has had a remarkable impact on my health, so I recommend trying it!
Read More
7.5
Less heart attacks
281 people found this helpful
Two years ago, after my mother suffered a heart attack, she started taking coenzyme Q10. She saw an improvement in her condition, including the cessation of arrhythmia attacks after five months. Alongside Q10, she takes Omega 3, which I believe has helped improve her overall health. We've now been buying it from iHerb, as it’s significantly cheaper than in Russia. My husband and I have also started taking it, noticing increased energy levels.
Read More
7.5
Health improvement
132 people found this helpful
After being hospitalised with COVID, my health took a downward turn until I began taking coenzyme Q10. Since starting this supplement, I’ve experienced significant improvements, especially regarding the side effects from COVID. My energy and memory have increased, and even my skin condition is improving. Co Q10 seems crucial in aiding recovery and protecting cells from damage. I also take various other supplements and face serums.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
We explored the potential of coenzyme Q10 (CoQ) in combination with selenium (Se) to improve liver health in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH). Our recent study involved male C57BL/6J mice fed a methionine choline-deficient diet, known to induce liver problems. The treatment groups received CoQ, Se, or both substances together for four weeks, while a control group received a methionine choline-sufficient diet.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
The results revealed that both CoQ and Se, particularly when used in combination, significantly reduced liver inflammation, fibrosis, and fat accumulation. We observed that these antioxidants alleviated oxidative stress and decreased markers of lipid peroxidation, alongside improving liver enzyme levels in the mice's blood. Importantly, the combination therapy also appeared to support cellular health by regulating proteins related to a specific type of cell death known as ferroptosis.
Our findings suggest that CoQ, especially in tandem with selenium, has therapeutic potential for managing liver diseases like MASH. This research opens doors for deeper investigations into antioxidant treatments for liver health, showcasing how we might leverage natural compounds for better outcomes in metabolic liver conditions.
Read More
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Read More
9
We explored the detrimental effects of chronic alcohol consumption on liver health, particularly focusing on how coenzyme Q10 (CoQ10) might help mitigate this damage. By conducting a study with rats, we investigated the relationship between ethanol-induced hepatotoxicity and the activation of specific inflammatory pathways.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
Read More
9
CoQ10 shows protective potential
We set out to explore how Coenzyme Q10 (CoQ) might guard against liver damage caused by aluminum phosphide (AlP) poisoning. This type of poisoning is a serious issue in many countries and can have dire consequences for organ health, especially the liver.
Our study involved several groups of subjects, some receiving CoQ treatment while others were exposed to AlP alone. We examined the effects of CoQ at various doses, looking closely at liver function and health indicators, such as certain enzymes and oxidative stress markers.
Our findings showed that AlP treatment led to significant liver damage, decreasing the activity of important mitochondrial components and raising oxidative stress levels. However, when we administered CoQ, we observed a noteworthy improvement in liver health markers and a reduction in apoptosis, or cell death. This suggests that CoQ may help support liver function by protecting against oxidative damage and maintaining mitochondrial health.
In summary, Coenzyme Q10 appears to play a beneficial role in combating liver toxicity caused by AlP poisoning, showcasing its potential as a protective treatment.
Our study involved several groups of subjects, some receiving CoQ treatment while others were exposed to AlP alone. We examined the effects of CoQ at various doses, looking closely at liver function and health indicators, such as certain enzymes and oxidative stress markers.
Our findings showed that AlP treatment led to significant liver damage, decreasing the activity of important mitochondrial components and raising oxidative stress levels. However, when we administered CoQ, we observed a noteworthy improvement in liver health markers and a reduction in apoptosis, or cell death. This suggests that CoQ may help support liver function by protecting against oxidative damage and maintaining mitochondrial health.
In summary, Coenzyme Q10 appears to play a beneficial role in combating liver toxicity caused by AlP poisoning, showcasing its potential as a protective treatment.
Read More
9
Coenzyme Q10 aids liver cancer treatment
This study explored how coenzyme Q10 (Q10) affects liver disease, particularly in hepatocellular carcinoma cells known as HepG2. We found that Q10 serves as a potent antioxidant, showing promise in reducing oxidative stress in these cancer cells. Our analysis revealed that Q10 treatment led to decreased oxidative stress products and enhanced the cells' antioxidant capacity.
Interestingly, while Q10 reduced levels of the Nrf2 protein associated with cancer cell survival, another compound called catharanthine had the opposite effect by increasing Nrf2 levels. This distinction is crucial, as Nrf2 plays a role in how cancer cells respond to treatment. Notably, we observed that Q10 also lowered the expression of certain proteins linked to metastasis and drug resistance, namely MMP-9 and MRP1.
When it came to inducing apoptosis, or programmed cell death, both treatments did increase apoptotic activity, but Q10 proved to be more effective than catharanthine. In fact, our findings suggest that even when used together, the benefits of catharanthine were overshadowed by Q10's stronger effects. Overall, our results indicate that coenzyme Q10 is not only beneficial for reducing oxidative stress but also plays a significant role in inducing cell death in liver cancer cells, making it a valuable candidate for further research in liver disease treatment.
Interestingly, while Q10 reduced levels of the Nrf2 protein associated with cancer cell survival, another compound called catharanthine had the opposite effect by increasing Nrf2 levels. This distinction is crucial, as Nrf2 plays a role in how cancer cells respond to treatment. Notably, we observed that Q10 also lowered the expression of certain proteins linked to metastasis and drug resistance, namely MMP-9 and MRP1.
When it came to inducing apoptosis, or programmed cell death, both treatments did increase apoptotic activity, but Q10 proved to be more effective than catharanthine. In fact, our findings suggest that even when used together, the benefits of catharanthine were overshadowed by Q10's stronger effects. Overall, our results indicate that coenzyme Q10 is not only beneficial for reducing oxidative stress but also plays a significant role in inducing cell death in liver cancer cells, making it a valuable candidate for further research in liver disease treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved liver health
3049 people found this helpful
I want to share my experience with coenzyme Q10. I noticed numbness in my legs while sitting for long hours. After taking coenzyme Q10 daily for over two years, along with fish oil, my liver responded well, and the nocturnal pain diminished. I recently made a long car trip without leg issues, and I no longer feel cold in winter. Coenzyme Q10 has had a remarkable impact on my health, so I recommend trying it!
Read More
7.5
Less heart attacks
281 people found this helpful
Two years ago, after my mother suffered a heart attack, she started taking coenzyme Q10. She saw an improvement in her condition, including the cessation of arrhythmia attacks after five months. Alongside Q10, she takes Omega 3, which I believe has helped improve her overall health. We've now been buying it from iHerb, as it’s significantly cheaper than in Russia. My husband and I have also started taking it, noticing increased energy levels.
Read More
7.5
Health improvement
132 people found this helpful
After being hospitalised with COVID, my health took a downward turn until I began taking coenzyme Q10. Since starting this supplement, I’ve experienced significant improvements, especially regarding the side effects from COVID. My energy and memory have increased, and even my skin condition is improving. Co Q10 seems crucial in aiding recovery and protecting cells from damage. I also take various other supplements and face serums.
Read More
6
Increased energy levels
111 people found this helpful
I have found this vitamin to be invaluable. I often felt tired and struggled to complete daily tasks, but since taking coenzyme Q10, my energy levels have noticeably increased. I can go about my day much more easily now. Additionally, it offers a vegan-friendly option, making it suitable for those with allergies or sensitivities.
Read More
9
Numbness alleviated
20 people found this helpful
I ordered Coenzyme Q10 for my father, who had been experiencing leg numbness during long drives and while watching television. Since he started taking it over two years ago, alongside Omega 3, he has not faced any issues. His overall health has improved, particularly concerning liver health. It has made a noticeable difference, and I’m grateful for the positive effects it has had on him.
Read More
Frequently Asked Questions
9
Numbness alleviated
20 people found this helpful
I ordered Coenzyme Q10 for my father, who had been experiencing leg numbness during long drives and while watching television. Since he started taking it over two years ago, alongside Omega 3, he has not faced any issues. His overall health has improved, particularly concerning liver health. It has made a noticeable difference, and I’m grateful for the positive effects it has had on him.
7.5
Increased energy
1 people found this helpful
I have been purchasing Coenzyme Q10 for my father, who suffers from mild heart valve disease. After one month at two capsules daily, he feels more energetic and is finding it easier to play table tennis. Even his friend has reported improvement after using it. I believe that smaller dosages are sufficient for us, and I appreciate this affordable product.
9
Improved liver health
3049 people found this helpful
I want to share my experience with coenzyme Q10. I noticed numbness in my legs while sitting for long hours. After taking coenzyme Q10 daily for over two years, along with fish oil, my liver responded well, and the nocturnal pain diminished. I recently made a long car trip without leg issues, and I no longer feel cold in winter. Coenzyme Q10 has had a remarkable impact on my health, so I recommend trying it!
7.5
Less heart attacks
281 people found this helpful
Two years ago, after my mother suffered a heart attack, she started taking coenzyme Q10. She saw an improvement in her condition, including the cessation of arrhythmia attacks after five months. Alongside Q10, she takes Omega 3, which I believe has helped improve her overall health. We've now been buying it from iHerb, as it’s significantly cheaper than in Russia. My husband and I have also started taking it, noticing increased energy levels.
6
Increased energy levels
111 people found this helpful
I have found this vitamin to be invaluable. I often felt tired and struggled to complete daily tasks, but since taking coenzyme Q10, my energy levels have noticeably increased. I can go about my day much more easily now. Additionally, it offers a vegan-friendly option, making it suitable for those with allergies or sensitivities.
7.5
Health improvement
132 people found this helpful
After being hospitalised with COVID, my health took a downward turn until I began taking coenzyme Q10. Since starting this supplement, I’ve experienced significant improvements, especially regarding the side effects from COVID. My energy and memory have increased, and even my skin condition is improving. Co Q10 seems crucial in aiding recovery and protecting cells from damage. I also take various other supplements and face serums.
9
Supports liver health
2 people found this helpful
Many medications hinder liver function by reducing the production of CoQ10, which is essential for rebuilding damaged cells. If you’re taking statins or diabetes medications, a CoQ10 supplement is definitely worth considering to support your health, as it aids in liver health.
We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.
Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.
9
We explored the detrimental effects of chronic alcohol consumption on liver health, particularly focusing on how coenzyme Q10 (CoQ10) might help mitigate this damage. By conducting a study with rats, we investigated the relationship between ethanol-induced hepatotoxicity and the activation of specific inflammatory pathways.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
The study involved giving rats increasing doses of ethanol over 30 days to induce liver damage, followed by treatment with CoQ10 in varying doses. We measured several liver health indicators and observed how CoQ10 affected inflammation and oxidative stress related to liver toxicity.
Our findings revealed that CoQ10 treatment significantly reduced liver damage markers and inflammation levels linked to the NLRP3/caspase-1/IL-1β pathway. Notably, we discovered that CoQ10 was more effective than its analog, idebenone (IDE), in protecting the liver from the harmful effects of alcohol.
This research is promising, as it highlights CoQ10's potential to serve as a therapeutic option for treating liver disease caused by alcohol consumption, shedding light on its antioxidant and anti-inflammatory properties.
8
Coenzyme Q10 protects liver health
We designed a study to investigate the protective effects of Coenzyme Q10 (CoQ10) against liver damage caused by cyclophosphamide, a medication often used in cancer treatment. The research involved 35 male Wistar albino rats divided into several groups, including a control group and those receiving cyclophosphamide alone or in combination with CoQ10.
Our observations highlighted that cyclophosphamide increased cholesterol, creatinine, and urea levels, indicating liver stress and potential damage. However, those rats treated with CoQ10 not only showed a reduction in these harmful markers but also a notable decrease in malondialdehyde levels, which are indicators of oxidative stress. Additionally, CoQ10 helped restore important antioxidant enzyme activities, suggesting its role in counteracting the oxidative stress induced by cyclophosphamide.
Interestingly, we also observed benefits on DNA integrity and histological health of the liver in those receiving CoQ10 alongside cyclophosphamide. This points towards its potential as a protective agent against drug-induced liver damage. Ultimately, our findings suggest that CoQ10 may offer significant protective effects against oxidative stress and other damaging processes in the liver when faced with cyclophosphamide treatment.
Our observations highlighted that cyclophosphamide increased cholesterol, creatinine, and urea levels, indicating liver stress and potential damage. However, those rats treated with CoQ10 not only showed a reduction in these harmful markers but also a notable decrease in malondialdehyde levels, which are indicators of oxidative stress. Additionally, CoQ10 helped restore important antioxidant enzyme activities, suggesting its role in counteracting the oxidative stress induced by cyclophosphamide.
Interestingly, we also observed benefits on DNA integrity and histological health of the liver in those receiving CoQ10 alongside cyclophosphamide. This points towards its potential as a protective agent against drug-induced liver damage. Ultimately, our findings suggest that CoQ10 may offer significant protective effects against oxidative stress and other damaging processes in the liver when faced with cyclophosphamide treatment.
4
We aimed to understand how coenzyme Q10, an antioxidant, might influence patients suffering from non-alcoholic fatty liver disease (NAFLD). In our systematic review and meta-analysis, we examined various randomized controlled trials that utilized CoQ10 as part of the treatment regimen for NAFLD.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
The findings from the six studies we reviewed showed an overall non-significant decrease in lipid profiles, which includes total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Additionally, liver enzymes such as aspartate transaminase and alanine transaminase tended to decline as well, but these results did not reach statistical significance across the board.
However, when we performed sensitivity analysis by excluding certain studies, we noted significant reductions in specific liver enzymes. Our subgroup analyses even revealed that the effects of coenzyme Q10 varied based on the dosage given and the duration of treatment. Despite these nuances, no publication bias was detected, reinforcing the reliability of the existing studies.
Overall, while there isn't a broad significant benefit observed from CoQ10 supplementation for NAFLD patients, our findings suggest that it may have beneficial effects under certain conditions. This indicates a need for further research to uncover the specific circumstances in which CoQ10 might be effective.
7
We aimed to investigate how coenzyme Q10 (CoQ10) affects liver damage related to methotrexate (MTX), a drug commonly used for treating cancers and autoimmune diseases. In our study involving twenty-four female Wistar albino rats, we divided the animals into four distinct groups. Some received only MTX, while others were treated with both MTX and CoQ10 over a week-long period.
Through diligent analysis, we noted that the use of CoQ10 showed protective effects against MTX-induced liver damage. Histopathological examinations revealed increased apoptosis, fibrosis, and inflammation in the MTX-only group, but these adverse effects notably decreased in the group that also received CoQ10.
However, an unexpected finding emerged: the combination of MTX and CoQ10 led to fatty liver degeneration and elevated levels of certain oxidative stress markers. This suggests that while CoQ10 can offer some protective benefits to the liver, its concurrent use with MTX raises concerns that merit further investigation.
In summary, while CoQ10 demonstrates some advantages in alleviating liver toxicity from MTX, the emergence of fatty degeneration in combined treatments prompts a careful reevaluation of its co-administration.
Through diligent analysis, we noted that the use of CoQ10 showed protective effects against MTX-induced liver damage. Histopathological examinations revealed increased apoptosis, fibrosis, and inflammation in the MTX-only group, but these adverse effects notably decreased in the group that also received CoQ10.
However, an unexpected finding emerged: the combination of MTX and CoQ10 led to fatty liver degeneration and elevated levels of certain oxidative stress markers. This suggests that while CoQ10 can offer some protective benefits to the liver, its concurrent use with MTX raises concerns that merit further investigation.
In summary, while CoQ10 demonstrates some advantages in alleviating liver toxicity from MTX, the emergence of fatty degeneration in combined treatments prompts a careful reevaluation of its co-administration.
References
- Choi H, Choi J, Go Y, Chung J. Coenzyme Q and Selenium Co-Supplementation Alleviate Methionine Choline-Deficient Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice. Nutrients. 2025;17. 10.3390/nu17020229
- Aydin I, Erisgin Z, Cinar E, Barak MZ, Tekelioglu Y, et al. Should combined MTX and CoQ10 use be reconsidered in terms of steatosis? A biochemical, flow cytometry, histopathological experimental study. Drug Chem Toxicol. 2024. 10.1080/01480545.2024.2442660
- Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. 10.1186/s12933-024-02326-8
- Yoladi FB, Palabiyik-Yucelik SS, Bahador Zirh E, Halici Z, Baydar T. Effects of idebenone and coenzyme Q10 on NLRP3/caspase-1/IL-1β pathway regulation on ethanol-induced hepatotoxicity in rats. Drug Chem Toxicol. 2024;47:1205. 10.1080/01480545.2024.2351191
- Hooshangi Shayesteh MR, Hami Z, Chamanara M, Parvizi MR, Golaghaei A, et al. Evaluation of the protective effect of coenzyme Q on hepatotoxicity caused by acute phosphine poisoning. Int J Immunopathol Pharmacol. 2024;38:3946320241250286. 10.1177/03946320241250286
- Akbel E, Kucukkurt I, Ince S, Demirel HH, Acaroz DA, et al. Investigation of protective effect of resveratrol and coenzyme Q against cyclophosphamide-induced lipid peroxidation, oxidative stress and DNA damage in rats. Toxicol Res (Camb). 2024;13:tfad123. 10.1093/toxres/tfad123
- Heidari-Kalvani N, Alizadeh-Fanalou S, Yarahmadi S, Fallah S, Alipourfard I, et al. Investigation of the effects of catharanthine and Q10 on Nrf2 and its association with MMP-9, MRP1, and Bcl-2 and apoptosis in a model of hepatocellular carcinoma. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:2507. 10.1007/s00210-023-02767-0
- Nalbant MA, Eroğlu O. Effects of Pyrroloquinoline Quinone (PQQ) and Coenzyme Q10 on Mitochondrial Genes, MitomiRs and Cellular Properties in HepG2 Cell Line. Cell Mol Biol (Noisy-le-grand). 2023;69:60. 10.14715/cmb/2023.69.4.9
- Ardekani A, Tabrizi R, Maleki E, Bagheri Lankarani K, Heydari ST, et al. Effects of coenzyme Q10 supplementation on lipid profiles and liver enzymes of nonalcoholic fatty liver disease (NAFLD) patients: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2023;11:2580. 10.1002/fsn3.3315
- Hibino M, Maeki M, Tokeshi M, Ishitsuka Y, Harashima H, et al. A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury. Sci Rep. 2023;13:6961. 10.1038/s41598-023-33893-7
- He X, Liang SM, Wang HQ, Tao L, Sun FF, et al. Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner. Toxicol Appl Pharmacol. 2023;465:116452. 10.1016/j.taap.2023.116452
